' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 15 Researches
7.3
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%**
Saturated Fat
< 0.5 g
2%**
Polyunsaturated Fat
0.5 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Omega-3 Fatty Acids:
Eicosapentaenoic Acid (EPA)
180 mg
†
Docosahexaenoic Acid (DHA)
120 mg
†
Top Medical Research Studies
9
Fish oil improves knee function
Efficacy and Safety of Fish Oil in Treatment of Knee Osteoarthritis.
Highly relevant to knee osteoarthritis
We explored how fish oil, rich in docosahexaenoic acid (DHA), can impact knee pain, particularly for those suffering from osteoarthritis. In our study, we involved 75 participants, divided into three groups, each taking either 1,000 mg or 2,000 mg of fish oil daily for eight weeks. We carefully measured their knee pain and walking abilities before and after the supplementation.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
Read More
9
DHA alleviates knee arthritis pain
Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund's Adjuvant-induced knee arthritis.
Study directly assesses DHA's effect
We explored the impacts of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on knee pain and inflammation in a mouse model of knee arthritis. Our objective was to see if DHA could ease spontaneous pain, reduce swelling, and improve mobility in mice that had been induced with arthritis using Complete Freund's Adjuvant (CFA).
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Read More
7
17-HDHA linked to knee pain relief
Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans.
High relevance to knee pain study
We set out to investigate how a compound called 17-HDHA, a precursor to docosahexaenoic acid (DHA), influences knee pain in people suffering from osteoarthritis. Our research involved two groups: healthy volunteers and individuals with knee osteoarthritis.
We measured levels of 17-HDHA and several other resolvins in participants and assessed their heat pain sensitivity as well as their knee pain. Interestingly, we found that higher levels of 17-HDHA were linked to increased heat pain thresholds, meaning individuals felt less pain when exposed to heat. Moreover, knee osteoarthritis patients with higher levels of 17-HDHA reported lower pain scores, suggesting a potential analgesic effect.
However, it's important to note that the other resolvins tested, including D-series and E-series resolvins, did not show a significant association with either heat pain sensitivity or osteoarthritis pain. Additionally, the effects of 17-HDHA appeared to be independent of DHA levels in the body. This suggests that 17-HDHA itself may play a crucial role in managing knee pain in osteoarthritis patients.
We measured levels of 17-HDHA and several other resolvins in participants and assessed their heat pain sensitivity as well as their knee pain. Interestingly, we found that higher levels of 17-HDHA were linked to increased heat pain thresholds, meaning individuals felt less pain when exposed to heat. Moreover, knee osteoarthritis patients with higher levels of 17-HDHA reported lower pain scores, suggesting a potential analgesic effect.
However, it's important to note that the other resolvins tested, including D-series and E-series resolvins, did not show a significant association with either heat pain sensitivity or osteoarthritis pain. Additionally, the effects of 17-HDHA appeared to be independent of DHA levels in the body. This suggests that 17-HDHA itself may play a crucial role in managing knee pain in osteoarthritis patients.
Read More
Most Useful Reviews
8.8
Alleviated knee pain
It helped me alleviate certain age-related pain, particularly knee pain. It's extremely effective.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 15 Researches
7.3
9
Eicosapentaenoic Acid Reduces Knee Pain
Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial.
Study explores combined supplement effects
We conducted a study to investigate how eicosapentaenoic acid (EPA), a component of omega-3 fatty acids, impacts knee pain in healthy adults over the age of 40 with persistent discomfort. The study was structured as a randomized, double-blind, controlled clinical trial, which means that participants were assigned to either an EPA product or a placebo without knowing which they were receiving.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
Read More
9
Eicosapentaenoic acid enhances knee pain relief
Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis.
Combination therapy relevance highlighted
We conducted a comprehensive study involving 177 patients with moderate to severe osteoarthritis (OA) affecting their hips or knees. Over 26 weeks, participants were divided into two groups. One group received glucosamine sulfate combined with omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The other group was treated with glucosamine sulfate alone.
Our main focus was to determine whether the combined treatment provided any notable benefits over glucosamine alone when it came to easing knee pain. We used the WOMAC score to assess pain, stiffness, and overall function in the participants. When we looked at the significant reduction of pain, more than 92% from both groups experienced some relief, but the combination treatment showed a higher response rate of 44%, compared to 32% in the glucosamine-only group.
Although both treatments appeared safe over the study duration, the statistical differences indicate that adding omega-3s can be beneficial for those specifically hoping for greater relief. We also noted that symptoms like morning stiffness and knee pain showed improvements, with greater reductions in the group taking the combination treatment. This suggests that eicosapentaenoic acid may provide added value in managing knee pain due to osteoarthritis, particularly for patients looking to maximize their treatment benefits.
Our main focus was to determine whether the combined treatment provided any notable benefits over glucosamine alone when it came to easing knee pain. We used the WOMAC score to assess pain, stiffness, and overall function in the participants. When we looked at the significant reduction of pain, more than 92% from both groups experienced some relief, but the combination treatment showed a higher response rate of 44%, compared to 32% in the glucosamine-only group.
Although both treatments appeared safe over the study duration, the statistical differences indicate that adding omega-3s can be beneficial for those specifically hoping for greater relief. We also noted that symptoms like morning stiffness and knee pain showed improvements, with greater reductions in the group taking the combination treatment. This suggests that eicosapentaenoic acid may provide added value in managing knee pain due to osteoarthritis, particularly for patients looking to maximize their treatment benefits.
Read More
9
Omega-3 improves knee pain relief
Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial.
Significant pain reduction observed
We conducted a compelling study to investigate how docosahexaenoic acid (DHA), often found in omega-3 supplements, influences knee pain in individuals aged 40 and older. The research was carefully designed as a randomized, double-blind, controlled clinical trial with four groups over an 8-week period. The participants dealt with persistent knee discomfort, scoring more than 3 on a visual analog scale for pain.
Among the groups, some received DHA alongside an omega-3 product called AvailOm, while others were given the omega-3 product alone or a placebo. Notably, those consuming the combined treatment of DHA and AvailOm showed improvements in both quality of life and muscle strength. There was a significant reduction in pain levels for participants taking AvailOm compared to those on placebo, particularly noticeable by the eighth week.
The study findings suggested that the omega-3 product effectively reduced pain perception and enhanced physical functionalities, including better performance on the Up and Go test. While the overall increase in omega-3 fatty acids was encouraging, the specific contributions of DHA to these improvements remain ambiguous due to the lack of isolation of DHA's effects in the results.
Overall, our study presents promising evidence that omega-3 supplementation can provide relief from knee pain and enhance quality of life in older adults suffering from this condition, though the unique role of DHA warrants further exploration.
Among the groups, some received DHA alongside an omega-3 product called AvailOm, while others were given the omega-3 product alone or a placebo. Notably, those consuming the combined treatment of DHA and AvailOm showed improvements in both quality of life and muscle strength. There was a significant reduction in pain levels for participants taking AvailOm compared to those on placebo, particularly noticeable by the eighth week.
The study findings suggested that the omega-3 product effectively reduced pain perception and enhanced physical functionalities, including better performance on the Up and Go test. While the overall increase in omega-3 fatty acids was encouraging, the specific contributions of DHA to these improvements remain ambiguous due to the lack of isolation of DHA's effects in the results.
Overall, our study presents promising evidence that omega-3 supplementation can provide relief from knee pain and enhance quality of life in older adults suffering from this condition, though the unique role of DHA warrants further exploration.
Read More
9
Fish oil improves knee function
Efficacy and Safety of Fish Oil in Treatment of Knee Osteoarthritis.
Highly relevant to knee osteoarthritis
We explored how fish oil, rich in docosahexaenoic acid (DHA), can impact knee pain, particularly for those suffering from osteoarthritis. In our study, we involved 75 participants, divided into three groups, each taking either 1,000 mg or 2,000 mg of fish oil daily for eight weeks. We carefully measured their knee pain and walking abilities before and after the supplementation.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
Read More
9
DHA alleviates knee arthritis pain
Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund's Adjuvant-induced knee arthritis.
Study directly assesses DHA's effect
We explored the impacts of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on knee pain and inflammation in a mouse model of knee arthritis. Our objective was to see if DHA could ease spontaneous pain, reduce swelling, and improve mobility in mice that had been induced with arthritis using Complete Freund's Adjuvant (CFA).
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
8.8
Alleviated knee pain
It helped me alleviate certain age-related pain, particularly knee pain. It's extremely effective.
